Inhibition of delayed-type hypersensitivity by heparin depleted of anticoagulant activity
MS Sy, E Schneeberger, R McCluskey, MI Greene… - Cellular …, 1983 - Elsevier
The intravenous or intraperitoneal injection of heparin fractions depleted of anticoagulant
activity (HFDA) into mice, either at the time of immunization or challenge, inhibited
haptenspecific delayed-type hypersensitivity (DTH) reactions. The loss was not due to
functional elimination of sensitized lymphocytes, since mice sensitized with the contactant
and then treated with HFDA retained their ability to transfer reactivity into normal syngeneic
recipients. In contrast, lymphocytes from sensitized mice were unable to produce DTH …
activity (HFDA) into mice, either at the time of immunization or challenge, inhibited
haptenspecific delayed-type hypersensitivity (DTH) reactions. The loss was not due to
functional elimination of sensitized lymphocytes, since mice sensitized with the contactant
and then treated with HFDA retained their ability to transfer reactivity into normal syngeneic
recipients. In contrast, lymphocytes from sensitized mice were unable to produce DTH …