[HTML][HTML] Regulation of SOCS-1 expression by translational repression
A Gregorieff, S Pyronnet, N Sonenberg… - Journal of Biological …, 2000 - ASBMB
Accumulating evidence demonstrates that cytokine receptor signaling is negatively
regulated by a family of Src homology 2 domain-containing adaptor molecules termed
SOCS (suppressor of cytokinesignaling). Previous studies have indicated that the
expression of SOCS-related molecules is tightly controlled at the level of transcription.
Furthermore, it has been reported that SOCS polypeptides are relatively unstable in cells,
unless they are associated with elongins B and C. Herein, we document the existence of a …
regulated by a family of Src homology 2 domain-containing adaptor molecules termed
SOCS (suppressor of cytokinesignaling). Previous studies have indicated that the
expression of SOCS-related molecules is tightly controlled at the level of transcription.
Furthermore, it has been reported that SOCS polypeptides are relatively unstable in cells,
unless they are associated with elongins B and C. Herein, we document the existence of a …