Alterations of estrogen metabolism in systemic lupus erythematosus
RG Lahita, H Leon Bradlow, HG Kunkel… - … : Official Journal of the …, 1979 - Wiley Online Library
RG Lahita, H Leon Bradlow, HG Kunkel, J Fishman
Arthritis & Rheumatism: Official Journal of the American College …, 1979•Wiley Online LibraryEstradiol metabolism in 10 patients with systemic lupus erythematosus (SLE) and 29 normal
controls was studied by measurement of urinary metabolites after injection of labeled 3H‐
estradiol. Patients with SLE manifested increased 16‐hydroxylation of estrone. Diseased
men differed from diseased women to the extent that only 16α‐hydroxyestrone was elevated
in men, whereas women had elevations of both 16α‐hydroxyestrone and estriol. These data
suggest that patients with SLE have abnormal patterns of estradiol metabolism, leading to …
controls was studied by measurement of urinary metabolites after injection of labeled 3H‐
estradiol. Patients with SLE manifested increased 16‐hydroxylation of estrone. Diseased
men differed from diseased women to the extent that only 16α‐hydroxyestrone was elevated
in men, whereas women had elevations of both 16α‐hydroxyestrone and estriol. These data
suggest that patients with SLE have abnormal patterns of estradiol metabolism, leading to …
Abstract
Estradiol metabolism in 10 patients with systemic lupus erythematosus (SLE) and 29 normal controls was studied by measurement of urinary metabolites after injection of labeled 3H‐estradiol. Patients with SLE manifested increased 16‐hydroxylation of estrone. Diseased men differed from diseased women to the extent that only 16α‐hydroxyestrone was elevated in men, whereas women had elevations of both 16α‐hydroxyestrone and estriol. These data suggest that patients with SLE have abnormal patterns of estradiol metabolism, leading to increased estrogenic activity.
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