A comparison of transcriptional activation by ERα and ERβ
SM Cowley, MG Parker - The Journal of steroid biochemistry and molecular …, 1999 - Elsevier
SM Cowley, MG Parker
The Journal of steroid biochemistry and molecular biology, 1999•ElsevierWe have compared the ability of ERα and ERβ to stimulate transcription from a number of
reporter genes in different cell lines and demonstrate that the activity of AF1 in ERβ is
negligible compared with that of ERα on ERE based reporters. The activity of AF2 in ERα
and ERβ is similar and this is likely to reflect their similar ability to bind coactivators. As a
consequence, when transcription from a gene depends on both AF1 and AF2 the activity of
ERα greatly exceeds that of ERβ but when AF1 is not required ERα and ERβ have similar …
reporter genes in different cell lines and demonstrate that the activity of AF1 in ERβ is
negligible compared with that of ERα on ERE based reporters. The activity of AF2 in ERα
and ERβ is similar and this is likely to reflect their similar ability to bind coactivators. As a
consequence, when transcription from a gene depends on both AF1 and AF2 the activity of
ERα greatly exceeds that of ERβ but when AF1 is not required ERα and ERβ have similar …
We have compared the ability of ERα and ERβ to stimulate transcription from a number of reporter genes in different cell lines and demonstrate that the activity of AF1 in ERβ is negligible compared with that of ERα on ERE based reporters. The activity of AF2 in ERα and ERβ is similar and this is likely to reflect their similar ability to bind coactivators. As a consequence, when transcription from a gene depends on both AF1 and AF2 the activity of ERα greatly exceeds that of ERβ but when AF1 is not required ERα and ERβ have similar transcriptional activities.
Elsevier