[HTML][HTML] Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and …
PD Prasad, H Wang, R Kekuda, T Fujita, YJ Fei… - Journal of Biological …, 1998 - ASBMB
Previous studies have shown that a Na+-dependent transport system is responsible for the
transplacental transfer of the vitamins pantothenate and biotin and the essential metabolite
lipoate. We now report the isolation of a rat placental cDNA encoding a transport protein
responsible for this function. The cloned cDNA, when expressed in HeLa cells, induces Na+-
dependent pantothenate and biotin transport activities. The transporter is specific for
pantothenate, biotin, and lipoate. The Michaelis-Menten constant (K t) for the transport of …
transplacental transfer of the vitamins pantothenate and biotin and the essential metabolite
lipoate. We now report the isolation of a rat placental cDNA encoding a transport protein
responsible for this function. The cloned cDNA, when expressed in HeLa cells, induces Na+-
dependent pantothenate and biotin transport activities. The transporter is specific for
pantothenate, biotin, and lipoate. The Michaelis-Menten constant (K t) for the transport of …