[HTML][HTML] The clearance and metabolism of biotin administered intravenously to pigs in tracer and physiologic amounts is much more rapid than previously appreciated
KS Wang, DM Mock, GL Kearns - The Journal of nutrition, 2001 - Elsevier
Understanding of biotin pharmacokinetics and regulation of metabolism is essential for the
determination of the biotin requirement for humans. Using Landrace-Cambrough pigs as a
model, we initially demonstrated that biotin binding to protein accounts for only a small
percentage of the total biotin in plasma. A physiologic amount of [14 C] biotin was
administered intravenously to three pigs; nine blood samples were collected over 48 h.
Plasma concentrations of 14 C-labeled metabolites were negligible for the first 2 h after …
determination of the biotin requirement for humans. Using Landrace-Cambrough pigs as a
model, we initially demonstrated that biotin binding to protein accounts for only a small
percentage of the total biotin in plasma. A physiologic amount of [14 C] biotin was
administered intravenously to three pigs; nine blood samples were collected over 48 h.
Plasma concentrations of 14 C-labeled metabolites were negligible for the first 2 h after …