Earlier evidence suggests that transforming growth factor [beta](TGF [beta]) plays a
significant role in tumor progression and metastasis. The most likely mechanism of the
action of TGF [beta] is induction of immunosuppression in the host, allowing for unchecked
tumor growth and metastasis. We attempted to test that hypothesis and to compare antitumor
effects of anti-TGF [beta] antibody alone and in combination with interleukin-2 (IL-2). Six-to 8-
week-old female C57B1-6 mice were induced with murine B16 melanoma by tail vein …