Kinetics of early and late spleen colony development.

NS Wolf, GV Priestley - Experimental hematology, 1986 - europepmc.org
NS Wolf, GV Priestley
Experimental hematology, 1986europepmc.org
The kinetics of spleen colony development were studied with special emphasis upon the self-
replicative capacity of CFU-S, which are responsible for the early-or late-appearing spleen
colonies, and upon CFU-S migration in the days following transplantation. It was found that,
while the spleen colonies had a much lower daughter CFU-S content at eight days than at
11 or 12 days, many of the 8-day colonies remained in the spleen to become 12-day
colonies which had many daughter CFU-S. In addition, it was found that large numbers of …
The kinetics of spleen colony development were studied with special emphasis upon the self-replicative capacity of CFU-S, which are responsible for the early-or late-appearing spleen colonies, and upon CFU-S migration in the days following transplantation. It was found that, while the spleen colonies had a much lower daughter CFU-S content at eight days than at 11 or 12 days, many of the 8-day colonies remained in the spleen to become 12-day colonies which had many daughter CFU-S. In addition, it was found that large numbers of CFU-S were present in the splenic space between the colonies. Evidence was developed that these" intercolonial space" CFU-S were the founders of many of the late-appearing spleen colonies and that many or all of them were transported from the bone marrow to the spleen via the blood at varying times after the transplantation. Approximately one-half of the day-12 colony founders were found to arrive in the spleen after the third posttransplantation day.
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