[HTML][HTML] Induction of angiogenesis by expression of soluble type II transforming growth factor-β receptor in mouse hepatoma
KY Kim, SY Jeong, J Won, PD Ryu, MJ Nam - Journal of Biological …, 2001 - ASBMB
The biological effect of transforming growth factor-β (TGF-β) is cell type-specific and
complex. The precise role of TGF-β is not clear in vivo. To elucidate the regulation
mechanism of endogenous TGF-β on hepatoma progression, we modified the MH129F
mouse hepatoma cell with a retroviral vector encoding the extracellular region of type II TGF-
β receptor (TRII). Soluble TRII (TRIIs) blocked TGF-β binding to TRII on the membrane of
hepatoma cells. Growth of MH129F cells was inhibited by TGF-β1 treatment; however …
complex. The precise role of TGF-β is not clear in vivo. To elucidate the regulation
mechanism of endogenous TGF-β on hepatoma progression, we modified the MH129F
mouse hepatoma cell with a retroviral vector encoding the extracellular region of type II TGF-
β receptor (TRII). Soluble TRII (TRIIs) blocked TGF-β binding to TRII on the membrane of
hepatoma cells. Growth of MH129F cells was inhibited by TGF-β1 treatment; however …
