The reported actions of arachidonic acid in the adult pulmonary circulation are controversial.
Some authors reported that arachidonic acid causes only pulmonary vasoconstriction;
others have found decreases in pulmonary vascular resistance with low-dose infusions. We
have previously reported that arachidonic acid causes only pulmonary vasoconstriction in
perinatal lambs during both normoxia and hypoxia. The effects of arachidonic acid on
pulmonary vascular resistance were determined in adult sheep using an in situ pump …