Cell-cycle regulation in immunity, tolerance and autoimmunity
D Balomenos, C Martı́nez-A - Immunology today, 2000 - cell.com
D Balomenos, C Martı́nez-A
Immunology today, 2000•cell.comTo trigger an effective immune response, lymphocytes must proliferate. In addition to their
direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune
functions. Recent evidence suggests that these regulators are essential for T-cell function;
we argue that their study will provide clues for dissecting anergy and tolerance mechanisms,
as well as for intervention in autoimmune diseases.
direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune
functions. Recent evidence suggests that these regulators are essential for T-cell function;
we argue that their study will provide clues for dissecting anergy and tolerance mechanisms,
as well as for intervention in autoimmune diseases.
Abstract
To trigger an effective immune response, lymphocytes must proliferate. In addition to their direct involvement in cell-cycle progression, cell-cycle regulators might thus control immune functions. Recent evidence suggests that these regulators are essential for T-cell function; we argue that their study will provide clues for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.
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