Correlation between the concentration of serum anti-topoisomerase I autoantibodies and histological and biochemical alterations in the skin of tight skin mice
A Hatakeyama, KN Kasturi, I Wolf, RG Phelps… - Cellular …, 1996 - Elsevier
Cutaneous hyperplasia observed in tight skin mice is due to a mutation located on
chromosome 2. While homozygous mice diein utero, the heterozygotes survive. TSK
syndrome is associated with the presence of autoantibodies specific for scleroderma target
autoantigens. The presence of autoantibodies specific for topoisomerase I is characteristic of
both human and murine disease. We have generated two distinct genotypes of mice, TSK/+
and+/+ with respect to the TSK trait by breeding TSK mice with immunodeficient mouse …
chromosome 2. While homozygous mice diein utero, the heterozygotes survive. TSK
syndrome is associated with the presence of autoantibodies specific for scleroderma target
autoantigens. The presence of autoantibodies specific for topoisomerase I is characteristic of
both human and murine disease. We have generated two distinct genotypes of mice, TSK/+
and+/+ with respect to the TSK trait by breeding TSK mice with immunodeficient mouse …