Overexpression of Fas ligand (FasL) during malignant transformation in the large bowel and in Barrett's metaplasia of the esophagus
M Younes, MR Schwartz, D Finnie, A Younes - Human pathology, 1999 - Elsevier
Esophageal and colorectal adenocarcinomas overexpress Fas ligand (FasL), which can
protect them from immune surveillance. The aim of this work was to determine whether FasL
expression, and therefore FasL-dependent immune evasion, occurs early during malignant
transformation in Barrett's metaplasia (BM) of the esophagus, and in the large intestine.
Sections of formalin-fixed and paraffin-embedded tissue from esophageal and large bowel
biopsies and resection specimens were immunostained for FasL using standard …
protect them from immune surveillance. The aim of this work was to determine whether FasL
expression, and therefore FasL-dependent immune evasion, occurs early during malignant
transformation in Barrett's metaplasia (BM) of the esophagus, and in the large intestine.
Sections of formalin-fixed and paraffin-embedded tissue from esophageal and large bowel
biopsies and resection specimens were immunostained for FasL using standard …