The growth hormone-releasing peptide KP-102 induces c-fos expression in the arcuate nucleus
J Kamegai, O Hasegawa, S Minami, H Sugihara… - Molecular brain …, 1996 - Elsevier
Growth hormone-releasing hexapeptide (GHRP) stimulates GH secretion by acting on both
the pituitary and the hypothalamus through a poorly understood mechanism. To reveal the
hypothalamic action of GHRP, rat brains were processed for in situ hybridization for c-fos
mRNA as a marker of neuronal activity after systemic administration of a newly developed
GHRP, KP-102. Hypophysectomized adult male Wistar rats were administered KP-102
through an indwelling right atrial cannula. KP-102 treatment was accompanied by transient …
the pituitary and the hypothalamus through a poorly understood mechanism. To reveal the
hypothalamic action of GHRP, rat brains were processed for in situ hybridization for c-fos
mRNA as a marker of neuronal activity after systemic administration of a newly developed
GHRP, KP-102. Hypophysectomized adult male Wistar rats were administered KP-102
through an indwelling right atrial cannula. KP-102 treatment was accompanied by transient …