Type ICD36 Deficiency in Humans Is not Associated with Insulin Resistance Syndrome
H Yanai, H Chiba, M Morimoto… - Thrombosis and …, 2000 - thieme-connect.com
H Yanai, H Chiba, M Morimoto, GA Jamieson, K Matsuno
Thrombosis and Haemostasis, 2000•thieme-connect.comType I CD36 Deficiency in Humans Is not Associated with Insulin Resistance Syndrome Page 1
786 Letters to the Editor Dear Sir, A defective gene encoding for the membrane glycoprotein
CD36 has recently been proposed as an insulin resistance gene in spontaneously hypertensive
rats (SHR) based on increased blood triglyceride levels in SHR and reduced blood
triglyceride in transgenic mice overexpressing CD36 (1). In humans, however, we have now
found that type I CD36 deficiency, in which CD36 is absent in both platelets and monocytes …
786 Letters to the Editor Dear Sir, A defective gene encoding for the membrane glycoprotein
CD36 has recently been proposed as an insulin resistance gene in spontaneously hypertensive
rats (SHR) based on increased blood triglyceride levels in SHR and reduced blood
triglyceride in transgenic mice overexpressing CD36 (1). In humans, however, we have now
found that type I CD36 deficiency, in which CD36 is absent in both platelets and monocytes …
2 Yamamoto N, Akamatsu H, Sakuraba H, Yamazaki H, Tanoue K. Platelet glycoprotein IV (CD36) deficiency is associated with the absence (type I) or the presence (type II) of glycoprotein IV on monocytes. Blood 1994; 83: 392-7.
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