[HTML][HTML] Defective fatty acid uptake in the spontaneously hypertensive rat is a primary determinant of altered glucose metabolism, hyperinsulinemia, and myocardial …
T Hajri, A Ibrahimi, CT Coburn, FF Knapp… - Journal of Biological …, 2001 - ASBMB
Genetic linkage studies implicated deficiency of CD36, a membrane fatty acid (FA)
transporter, in the hypertriglyceridemia and hyperinsulinemia of the spontaneously
hypertensive rat (SHR). In this study we determined whether loss of CD36 function in FA
uptake is a primary determinant of the SHR phenotype. In vivo, tissue distribution of
iodinated, poorly oxidized β-methyliodophenyl pentadecanoic acid (BMIPP) was examined
2 h after its intravenous injection. Fatty acid transport was also measured in vitro over 20 to …
transporter, in the hypertriglyceridemia and hyperinsulinemia of the spontaneously
hypertensive rat (SHR). In this study we determined whether loss of CD36 function in FA
uptake is a primary determinant of the SHR phenotype. In vivo, tissue distribution of
iodinated, poorly oxidized β-methyliodophenyl pentadecanoic acid (BMIPP) was examined
2 h after its intravenous injection. Fatty acid transport was also measured in vitro over 20 to …