[HTML][HTML] The Toll-receptor family and control of innate immunity
EB Kopp, R Medzhitov - Current opinion in immunology, 1999 - Elsevier
EB Kopp, R Medzhitov
Current opinion in immunology, 1999•ElsevierInnate immune recognition is mediated by a system of germline-encoded receptors that
recognize conserved molecular patterns that are associated with microbial pathogens.
These receptors are coupled to signal transduction pathways that control expression of a
variety of inducible immune-response genes. Toll receptors and the associated signaling
pathways of nuclear factor κB may represent the most ancient host defense system found in
mammals, insects and plants.
recognize conserved molecular patterns that are associated with microbial pathogens.
These receptors are coupled to signal transduction pathways that control expression of a
variety of inducible immune-response genes. Toll receptors and the associated signaling
pathways of nuclear factor κB may represent the most ancient host defense system found in
mammals, insects and plants.
Innate immune recognition is mediated by a system of germline-encoded receptors that recognize conserved molecular patterns that are associated with microbial pathogens. These receptors are coupled to signal transduction pathways that control expression of a variety of inducible immune-response genes. Toll receptors and the associated signaling pathways of nuclear factor κB may represent the most ancient host defense system found in mammals, insects and plants.
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