Background/Aims: The extracellular matrix regulates hepatic development and regeneration,
modulating the maintenance of liver architecture in the differentiated state. The aim of this
work was to analyze how different extracellular matrix molecules modulate fetal hepatocyte
morphology, growth and differentiation. Methods: We cultured fetal hepatocytes either on
plastic or on different extracellular matrix proteins, ie, collagen I, fibronectin or ECL (entactin-
collagen IV-laminin) and we analyzed cell attachment, morphological organization …