[HTML][HTML] Protein tyrosine nitration in cytokine-activated murine macrophages
S Pfeiffer, A Lass, K Schmidt, B Mayer - Journal of Biological Chemistry, 2001 - ASBMB
Peroxynitrite, formed in a rapid reaction of nitric oxide (NO) and superoxide anion radical
(O⨪ 2), is thought to mediate protein tyrosine nitration in various inflammatory and infectious
diseases. However, a recent in vitro study indicated that peroxynitrite exhibits poor nitrating
efficiency at biologically relevant steady-state concentrations (Pfeiffer, S., Schmidt, K., and
Mayer, B.(2000) J. Biol. Chem. 275, 6346–6352). To investigate the molecular mechanism of
protein tyrosine nitration in intact cells, murine RAW 264.7 macrophages were activated with …
(O⨪ 2), is thought to mediate protein tyrosine nitration in various inflammatory and infectious
diseases. However, a recent in vitro study indicated that peroxynitrite exhibits poor nitrating
efficiency at biologically relevant steady-state concentrations (Pfeiffer, S., Schmidt, K., and
Mayer, B.(2000) J. Biol. Chem. 275, 6346–6352). To investigate the molecular mechanism of
protein tyrosine nitration in intact cells, murine RAW 264.7 macrophages were activated with …