Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon
R Deonarain, A Alcamí, M Alexiou, MJ Dallman… - Journal of …, 2000 - Am Soc Microbiol
R Deonarain, A Alcamí, M Alexiou, MJ Dallman, DR Gewert, ACG Porter
Journal of virology, 2000•Am Soc MicrobiolWe have generated mice lacking the gene for beta interferon and report that they are highly
susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral
induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that
beta interferon does not prime its own expression.
susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral
induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that
beta interferon does not prime its own expression.
Abstract
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.
American Society for Microbiology