[HTML][HTML] p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide
L Navarro, M David - Journal of Biological Chemistry, 1999 - ASBMB
Interferon regulatory factor 3 (IRF3) is known to participate in the transcriptional induction of
interferon (IFN) α and IFNβ genes, as well as of a number of interferon-stimulated genes
(ISGs), as a result of viral infection. In the present study we demonstrate the activation of
IRF3 followed by ISG induction after exposure of cells to the bacterial cell wall component
lipopolysaccharide. Engagement of Toll-like receptors by lipopolysaccharide triggered the
nuclear translocation of IRF3, followed by its DNA binding and the subsequent induction of …
interferon (IFN) α and IFNβ genes, as well as of a number of interferon-stimulated genes
(ISGs), as a result of viral infection. In the present study we demonstrate the activation of
IRF3 followed by ISG induction after exposure of cells to the bacterial cell wall component
lipopolysaccharide. Engagement of Toll-like receptors by lipopolysaccharide triggered the
nuclear translocation of IRF3, followed by its DNA binding and the subsequent induction of …