Plasma tumor necrosis factor-a (TNF-a) levels in Gaucher disease
H Michelakakis, C Spanou, A Kondyli… - … et Biophysica Acta (BBA …, 1996 - Elsevier
H Michelakakis, C Spanou, A Kondyli, E Dimitriou, S Van Weely, CEM Hollak, MHJ Van Oers…
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1996•ElsevierTumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with
different types of Gaucher disease (GD) and patients with other lysosomal storage diseases.
The highest TNF-a levels were observed in the most severe neuronopathic type of GD,
exceeding those found in healthy individuals as well as patients with other lysosomal
disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5
X the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated …
different types of Gaucher disease (GD) and patients with other lysosomal storage diseases.
The highest TNF-a levels were observed in the most severe neuronopathic type of GD,
exceeding those found in healthy individuals as well as patients with other lysosomal
disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5
X the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated …
Tumor necrosis factor-a (TNF-a) levels were measured in the plasma of patients with different types of Gaucher disease (GD) and patients with other lysosomal storage diseases. The highest TNF-a levels were observed in the most severe neuronopathic type of GD, exceeding those found in healthy individuals as well as patients with other lysosomal disorders. Type I GD cases showed a wide range of TNF-a levels ranging from normal to 2.5 X the highest control value. TNF-a is a pleiotropic cytokine produced mainly by activated macrophages. Our data suggest that it may play a role in the pathophysiology of GD disease.
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