The morphogenesis of testicular degeneration induced in rats by orally administered 2, 5-hexanedione
RE Chapin, KT Morgan, JS Bus - Experimental and molecular pathology, 1983 - Elsevier
Abstract The neurotoxic hexacarbon 2, 5-hexanedione (2, 5-HD) produces testicular atrophy
in experimental animals. To examine the morphogenesis of the testicular lesion, 1.0% 2, 5-
HD was provided in the drinking water of adult F-344 rats for up to 6 weeks. After 3 weeks of
administration, there were occasional large vacuoles in the basal region of the germinal
epithelium. At 4 weeks, these vacuoles were much larger and more numerous; electron
microscopy demonstrated that they were derived from the smooth endoplasmic reticulum …
in experimental animals. To examine the morphogenesis of the testicular lesion, 1.0% 2, 5-
HD was provided in the drinking water of adult F-344 rats for up to 6 weeks. After 3 weeks of
administration, there were occasional large vacuoles in the basal region of the germinal
epithelium. At 4 weeks, these vacuoles were much larger and more numerous; electron
microscopy demonstrated that they were derived from the smooth endoplasmic reticulum …