Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.
Insulin Receptor Substrate-1 (IRS-1) is an endogenous cellular protein that is tyrosine
phosphorylated during stimulation of cells with insulin, IGF-1, and interleukin 4 (IL-4).
Phosphorylated IRS-1 regulates multiple regulatory pathways by recruiting signaling
molecules containing Src homology 2 domains (SH2 proteins). The 32D myeloid progenitor
cell line contains few insulin receptors and no detectable IRS-1. Expression of the insulin
receptor alone partially mediates insulin-stimulated microtubule-associated protein (MAP) …
phosphorylated during stimulation of cells with insulin, IGF-1, and interleukin 4 (IL-4).
Phosphorylated IRS-1 regulates multiple regulatory pathways by recruiting signaling
molecules containing Src homology 2 domains (SH2 proteins). The 32D myeloid progenitor
cell line contains few insulin receptors and no detectable IRS-1. Expression of the insulin
receptor alone partially mediates insulin-stimulated microtubule-associated protein (MAP) …