Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons
T Alonzi, G Middleton, S Wyatt, V Buchman… - Molecular and Cellular …, 2001 - Elsevier
The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and
PI3K/Akt signalling pathways. To assess the relative importance of these pathways in
promoting the survival of cytokine-dependent neurons, we conditionally inactivated STAT3
in mice and inhibited MEK, PI3K, and Akt in cultured neurons using pharmacological
reagents and by expressing specific inhibitory proteins. Inactivation of STAT3 enhanced the
death of the cytokine-dependent sensory neurons of the nodoseganglion in vivo and …
PI3K/Akt signalling pathways. To assess the relative importance of these pathways in
promoting the survival of cytokine-dependent neurons, we conditionally inactivated STAT3
in mice and inhibited MEK, PI3K, and Akt in cultured neurons using pharmacological
reagents and by expressing specific inhibitory proteins. Inactivation of STAT3 enhanced the
death of the cytokine-dependent sensory neurons of the nodoseganglion in vivo and …