STAT family of transcription factors in cytokine-mediated biological responses
K Takeda, S Akira - Cytokine & growth factor reviews, 2000 - Elsevier
STAT (signal transducers and activators of transcription) family, consisting of seven
members, is involved in cytokine signal transduction. Biological roles of each STAT family
protein have now been elucidated through studies of gene targeted mice. Stat1 knockout
mice are defective in interferon-mediated functions. Stat4 and Stat6 knockout mice show
defective responses to IL-12 and IL-4, respectively. Analyses of Stat5a and Stat5b knockout
mice reveal important roles in prolactin-mediated mammary gland development and growth …
members, is involved in cytokine signal transduction. Biological roles of each STAT family
protein have now been elucidated through studies of gene targeted mice. Stat1 knockout
mice are defective in interferon-mediated functions. Stat4 and Stat6 knockout mice show
defective responses to IL-12 and IL-4, respectively. Analyses of Stat5a and Stat5b knockout
mice reveal important roles in prolactin-mediated mammary gland development and growth …