Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

JD Morton, L Shimomura - Current opinion in lipidology, 1999 - journals.lww.com
JD Morton, L Shimomura
Current opinion in lipidology, 1999journals.lww.com
A family of transcription factors designated sterol regulatory element-binding proteins
(SREBPs) mediates the previously described end-product feedback regulation of cholesterol
biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid
synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the
coordinate regulation of SREBP-activated target genes. Curr Opin Lipidol
Abstract
A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes. Curr Opin Lipidol
Lippincott Williams & Wilkins