[HTML][HTML] Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic …
JR Graff, E Gabrielson, H Fujii, SB Baylin… - Journal of Biological …, 2000 - ASBMB
Metastatic progression of most common epithelial tumors involves a heterogeneous,
transient loss of expression of the homotypic cell adhesion protein, E-cadherin, rather than
the uniform loss of a functional protein resulting from coding region mutation. Indeed,
whereas E-cadherin loss may promote invasion, reexpression may facilitate cell survival
within metastatic deposits. The mechanisms underlying such plasticity are unclear. We now
show that the heterogeneous loss of E-cadherin expression in primary human breast …
transient loss of expression of the homotypic cell adhesion protein, E-cadherin, rather than
the uniform loss of a functional protein resulting from coding region mutation. Indeed,
whereas E-cadherin loss may promote invasion, reexpression may facilitate cell survival
within metastatic deposits. The mechanisms underlying such plasticity are unclear. We now
show that the heterogeneous loss of E-cadherin expression in primary human breast …