Polymorphic amino acid domains of the HLA-DQ molecule are associated with disease heterogeneity in myasthenia gravis

P Hjelmström, R Giscombe, AK Lefvert… - Journal of …, 1996 - Elsevier
The association between myasthenia gravis (MG) and polymorphic amino acid domains in
the HLA-DQ molecule was studied in 79 Swedish patients and 155 unrelated, population-
based controls. A domain unique for DQB1∗ 0201 was positively associated in MG patients
with thymic hyperplasia or an early disease onset, and two domains with residues common
to DQA1∗ 01 alleles or DQB1∗ 05 and DQB1∗ 06 alleles were negatively associated in
patients with thymic hyperplasia or an early disease onset. Our results suggest that MG …