[HTML][HTML] MinK-KvLQT1 Fusion Proteins, Evidence for Multiple Stoichiometries of the Assembled I sKChannel
W Wang, J Xia, RS Kass - Journal of Biological Chemistry, 1998 - ASBMB
I sK, a slowly activating delayed rectifier K+ current through channels formed by the
assembly of two channel proteins KvLQT1 and MinK, modulates the repolarization of cardiac
action potentials. Mutations that map to theKvLQT1 and minK genes account for more than
50% of an inherited cardiac disorder, the Long QT syndrome (Splawski, I., Tristani-Firouzi,
M., Lehmann, MH, Sanguinetti, MC, and Keating, MT (1997) Nat. Genet. 17, 338–340).
Despite the importance of these channels to human cardiac function, the molecular basis of …
assembly of two channel proteins KvLQT1 and MinK, modulates the repolarization of cardiac
action potentials. Mutations that map to theKvLQT1 and minK genes account for more than
50% of an inherited cardiac disorder, the Long QT syndrome (Splawski, I., Tristani-Firouzi,
M., Lehmann, MH, Sanguinetti, MC, and Keating, MT (1997) Nat. Genet. 17, 338–340).
Despite the importance of these channels to human cardiac function, the molecular basis of …