MFH‐1, a new member of the fork head domain family, is expressed in developing mesenchyme

N Miura, A Wanaka, M Tohyama, K Tanaka - FEBS letters, 1993 - Wiley Online Library
N Miura, A Wanaka, M Tohyama, K Tanaka
FEBS letters, 1993Wiley Online Library
We have isolated a novel mouse gene, MFH‐1 (mesenchyme fork head 1) that is related to
the Drosophila fork head and rat HNF3 genes. MFH‐1 encodes a distinct fork head domain
that is classified into a distinct subfamily. A recombinant MFH‐1 protein could bind to the
HNF3 binding site. MFH‐1 is expressed temporally in developing embryos, first in the non‐
notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head,
and limbs. Our results suggest that MFH‐1 might be involved in the formation of special …
We have isolated a novel mouse gene, MFH‐1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH‐1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH‐1 protein could bind to the HNF3 binding site. MFH‐1 is expressed temporally in developing embryos, first in the non‐notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH‐1 might be involved in the formation of special mesenchymal tissues.
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