[HTML][HTML] An electron microscopic study of thrombin-induced disseminated intravascular coagulation
W Margaretten, I Csavossy, DG Mckay - Blood, 1967 - Elsevier
W Margaretten, I Csavossy, DG Mckay
Blood, 1967•ElsevierAbstract The GENERALIZED SHWARTZMAN REACTION is ordinarily elicited in rabbits by
two appropriately spaced injections of bacterial endotoxin. 1 The lesion which identifies the
reaction, renal cortical necrosis, is due to an obstruction of the glomerular capillary
circulation by fibrin thrombi. 2 The occluding material has been identified as fibrin by
immunofluorescent 3 and electron microscopic methods. 4 An identical lesion can be
produced by the slow intravenous infusion of thrombin. 5 At the present time the majority of …
two appropriately spaced injections of bacterial endotoxin. 1 The lesion which identifies the
reaction, renal cortical necrosis, is due to an obstruction of the glomerular capillary
circulation by fibrin thrombi. 2 The occluding material has been identified as fibrin by
immunofluorescent 3 and electron microscopic methods. 4 An identical lesion can be
produced by the slow intravenous infusion of thrombin. 5 At the present time the majority of …
Abstract
The GENERALIZED SHWARTZMAN REACTION is ordinarily elicited in rabbits by two appropriately spaced injections of bacterial endotoxin.1The lesion which identifies the reaction, renal cortical necrosis, is due to an obstruction of the glomerular capillary circulation by fibrin thrombi.2 The occluding material has been identified as fibrin by immunofluorescent3 and electron microscopic methods.4 An identical lesion can be produced by the slow intravenous infusion of thrombin.5At the present time the majority of evidence supports the concept that the clotting episode is triggered by an effect of endotoxin on platelets.6Endotoxin induces aggregation of platelets in vitro7and in vivo8to release platelet factor 3.
Elsevier