The phosphoprotein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates
JM Louis, VW McFarland, P May, PT Mora - Biochimica et Biophysica Acta …, 1988 - Elsevier
The phosphoprotein p53 has been investigated mainly because of its relationship with
tumorigenic transformation. In this communication, we report that, during the embryonal
development of mouse and chicken, there is a decline in the steady-state levels of the p53
protein and an equal decline in p53 mRNA. During the development of the chicken, the
relative rates of p53 transcription appear to be constant. p53 mRNA is relatively stable (half-
life greater than 12 h) in both chicken and mouse embryos. We conclude that (i) the down …
tumorigenic transformation. In this communication, we report that, during the embryonal
development of mouse and chicken, there is a decline in the steady-state levels of the p53
protein and an equal decline in p53 mRNA. During the development of the chicken, the
relative rates of p53 transcription appear to be constant. p53 mRNA is relatively stable (half-
life greater than 12 h) in both chicken and mouse embryos. We conclude that (i) the down …