[HTML][HTML] Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation
Acute hypertonicity causes cell cycle delay and apoptosis in mouse renal inner medullary
collecting duct cells (mIMCD3) and increases GADD45 expression. Because the tumor
suppressor protein p53 may be involved in these effects, we have investigated the role of
p53 in mIMCD3 response to hyperosmotic stress. Acute elevation of osmolality with NaCl
addition from the control level of 320 mosmol/kg to 500–600 mosmol/kg greatly increased
the levels of total and Ser 15-phosphorylated p53 within 15 min. However, similar elevation …
collecting duct cells (mIMCD3) and increases GADD45 expression. Because the tumor
suppressor protein p53 may be involved in these effects, we have investigated the role of
p53 in mIMCD3 response to hyperosmotic stress. Acute elevation of osmolality with NaCl
addition from the control level of 320 mosmol/kg to 500–600 mosmol/kg greatly increased
the levels of total and Ser 15-phosphorylated p53 within 15 min. However, similar elevation …