[HTML][HTML] The bradykinin type 2 receptor is a target for p53-mediated transcriptional activation
Z Saifudeen, H Du, S Dipp, SS El-Dahr - Journal of Biological Chemistry, 2000 - ASBMB
The bradykinin type 2 receptor (BK2) is a developmentally regulated G protein-coupled
receptor that mediates diverse actions such as vascular reactivity, salt and water excretion,
inflammatory responses, and cell growth. However, little is known regarding regulation of the
BK2 gene. We report here that the rat BK2 receptor is transcriptionally regulated by the
tumor suppressor protein p53. The 5′-flanking region of the rat BK2 gene contains two p53-
like binding sites: a sequence at− 70 base pairs (P1 site) that is conserved in the murine and …
receptor that mediates diverse actions such as vascular reactivity, salt and water excretion,
inflammatory responses, and cell growth. However, little is known regarding regulation of the
BK2 gene. We report here that the rat BK2 receptor is transcriptionally regulated by the
tumor suppressor protein p53. The 5′-flanking region of the rat BK2 gene contains two p53-
like binding sites: a sequence at− 70 base pairs (P1 site) that is conserved in the murine and …