[HTML][HTML] Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA) n repeat element within an Alu sequence
KN Hogeveen, M Talikka, GL Hammond - Journal of Biological Chemistry, 2001 - ASBMB
Sex hormone-binding globulin (SHBG) is the major sex steroid-binding protein in human
plasma and is produced by the liver. Plasma SHBG levels vary considerably between
individuals and are influenced by hormonal, metabolic, and nutritional factors. We have now
found that a (TAAAA) n pentanucleotide repeat, located within an alu sequence at the 5′
boundary of the human SHBG promoter, influences its transcriptional activity in association
with downstream elements, including an SP1-binding site. Furthermore, SHBG alleles within …
plasma and is produced by the liver. Plasma SHBG levels vary considerably between
individuals and are influenced by hormonal, metabolic, and nutritional factors. We have now
found that a (TAAAA) n pentanucleotide repeat, located within an alu sequence at the 5′
boundary of the human SHBG promoter, influences its transcriptional activity in association
with downstream elements, including an SP1-binding site. Furthermore, SHBG alleles within …