Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor
KH Grabstein, J Eisenman, K Shanebeck, C Rauch… - Science, 1994 - science.org
KH Grabstein, J Eisenman, K Shanebeck, C Rauch, S Srinivasan, V Fung, C Beers…
Science, 1994•science.orgA cytokine was identified that stimulated the proliferation of T lymphocytes, and a
complementary DNA clone encoding this new T cell growth factor was isolated. The
cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues
and shares many biological properties with IL-2. Monoclonal antibodies to the β chain of the
IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-
2, indicating that IL-15 uses components of the IL-2 receptor.
complementary DNA clone encoding this new T cell growth factor was isolated. The
cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues
and shares many biological properties with IL-2. Monoclonal antibodies to the β chain of the
IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-
2, indicating that IL-15 uses components of the IL-2 receptor.
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the β chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
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