[HTML][HTML] Molecular cloning and expression of a novel β-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branches
JC Yeh, E Ong, M Fukuda - Journal of Biological Chemistry, 1999 - ASBMB
Mucin-type O-glycans are classified according to their core structures. Among them, cores 2
and 4 are important for having N-acetyllactosamine side chains, which can be further
modified to express various functional oligosaccharides. Previously, we discovered by
cloning cDNAs that the core 2 branching enzyme, termed core 2 β-1, 6-N-
acetylglucosaminyltransferase-leukocyte type (C2GnT-L), is highly homologous to the I
branching β-1, 6-N-acetylglucosaminyltransferase (IGnT)(Bierhuizen, MFA, Mattei, M.-G …
and 4 are important for having N-acetyllactosamine side chains, which can be further
modified to express various functional oligosaccharides. Previously, we discovered by
cloning cDNAs that the core 2 branching enzyme, termed core 2 β-1, 6-N-
acetylglucosaminyltransferase-leukocyte type (C2GnT-L), is highly homologous to the I
branching β-1, 6-N-acetylglucosaminyltransferase (IGnT)(Bierhuizen, MFA, Mattei, M.-G …