[HTML][HTML] Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in …
P-selectin, an adhesion receptor for leukocytes, is constitutively expressed in
megakaryocytes and endothelial cells. Tumor necrosis factor-α (TNF-α) or
lipopolysaccharide (LPS) increases synthesis of P-selectin in murine but not in human
endothelial cells. To identify potential species-specific and conserved mechanisms for
regulation of expression of P-selectin, we cloned the 5′-flanking region of the murine P-
selectin gene and compared its features with those previously reported for the human gene …
megakaryocytes and endothelial cells. Tumor necrosis factor-α (TNF-α) or
lipopolysaccharide (LPS) increases synthesis of P-selectin in murine but not in human
endothelial cells. To identify potential species-specific and conserved mechanisms for
regulation of expression of P-selectin, we cloned the 5′-flanking region of the murine P-
selectin gene and compared its features with those previously reported for the human gene …