[HTML][HTML] The binding of T cell-expressed P-selectin glycoprotein ligand-1 to E-and P-selectin is differentially regulated

E Borges, G Pendl, R Eytner, M Steegmaier… - Journal of Biological …, 1997 - ASBMB
The HECA452 carbohydrate epitope, also termed cutaneous lymphocyte antigen, is known
to bind to E-selectin and defines a human T cell subset preferentially found in inflamed skin.
Activated T cells can express a functional form of the P-selectin glycoprotein ligand-1 (PSGL-
1), the major ligand known for P-selectin. Here we show that PSGL-1 can exist in two forms,
of which only one carries the HECA452 epitope and binds to E-selectin, while the other only
binds to P-selectin. We have analyzed the glycoprotein ligands for E-and P-selectin on the …