Differential responses of collagen and glycosaminoglycan syntheses and cell proliferation to exogenous transforming growth factor β 1 in the developing mouse skin …
K Kishi, H Nakajima, S Tajima - British journal of plastic surgery, 1999 - Elsevier
Skin fibroblast cultures were established from mouse foetuses at days 14, 15, 16 and 18 of
gestation and from newborn mice. Modulations of mitotic and biosynthetic phenotypes of the
fibroblasts by transforming growth factor β1 (TGFβ1) were studied. Treatment of the
fibroblasts with TGFβ1 at doses of 1 and 10 ng/ml for 48 h resulted in significant stimulation
of cell proliferation in the 15-, 16-and 18-day foetal fibroblasts and a slight stimulation in the
14-day foetal fibroblasts. Treatment with TGFβ1 resulted in stimulation of collagen synthesis …
gestation and from newborn mice. Modulations of mitotic and biosynthetic phenotypes of the
fibroblasts by transforming growth factor β1 (TGFβ1) were studied. Treatment of the
fibroblasts with TGFβ1 at doses of 1 and 10 ng/ml for 48 h resulted in significant stimulation
of cell proliferation in the 15-, 16-and 18-day foetal fibroblasts and a slight stimulation in the
14-day foetal fibroblasts. Treatment with TGFβ1 resulted in stimulation of collagen synthesis …