[HTML][HTML] Local immune response in skin of generalized vitiligo patients: destruction of melanocytes is associated with the prominent presence of CLA+ T cells at the …
R Van Den Wijngaard, A Wankowicz-Kalinska… - Laboratory …, 2000 - Elsevier
In situ immune infiltrates in lesional, perilesional, and nonlesional skin biopsies from
patients with vitiligo were analyzed by immunohistochemistry and compared with immune
infiltrates found in the skin of normal healthy donors and relevant disease controls. An
increased influx of activated skin-homing T cells and macrophages were seen in the
perilesional biopsies. The overall percentages of cutaneous leukocyte-associated antigen-
positive (CLA+) T cells were similar to those found in normal healthy donors. This is …
patients with vitiligo were analyzed by immunohistochemistry and compared with immune
infiltrates found in the skin of normal healthy donors and relevant disease controls. An
increased influx of activated skin-homing T cells and macrophages were seen in the
perilesional biopsies. The overall percentages of cutaneous leukocyte-associated antigen-
positive (CLA+) T cells were similar to those found in normal healthy donors. This is …