Induction of selected chemokines in glial cells infected with Theiler's virus
JP Palma, BS Kim - Journal of neuroimmunology, 2001 - Elsevier
To elucidate the early events in Theiler's virus-induced demyelination, a model for human
multiple sclerosis (MS), chemokine gene activation in the central nervous system (CNS)
resident cells upon viral infection was investigated. Viral infection selectively upregulated
RANTES and IP-10 gene expression in primary astrocyte cultures and broader chemokine
genes in oligodendrocyte and microglia cultures. Both RANTES and IP-10 were stimulated
by proinflammatory cytokine interferon-gamma (IFNγ), but only RANTES by tumor necrosis …
multiple sclerosis (MS), chemokine gene activation in the central nervous system (CNS)
resident cells upon viral infection was investigated. Viral infection selectively upregulated
RANTES and IP-10 gene expression in primary astrocyte cultures and broader chemokine
genes in oligodendrocyte and microglia cultures. Both RANTES and IP-10 were stimulated
by proinflammatory cytokine interferon-gamma (IFNγ), but only RANTES by tumor necrosis …