Differential effect of Mn2+ on the hemin-controlled translational repressor and the double-stranded RNA-activated inhibitor
M Gross, DA Kaplansky - Biochimica et Biophysica Acta (BBA)-Gene …, 1983 - Elsevier
The inhibition of protein synthesis that occurs when rabbit reticulocyte lysate is incubated in
the absence of hemin is due to the activation of a protein kinase termed the hemin-controlled
translational repressor, and that occurring when reticulocyte lysate is incubated with a low
level of double-stranded RNA is mediated by the activation of a separate protein kinase
termed the double-stranded RNA-activated inhibitor. Both the hemin-controlled translational
repressor and the double-stranded RNA-activated inhibitor act by phosphorylating the M r …
the absence of hemin is due to the activation of a protein kinase termed the hemin-controlled
translational repressor, and that occurring when reticulocyte lysate is incubated with a low
level of double-stranded RNA is mediated by the activation of a separate protein kinase
termed the double-stranded RNA-activated inhibitor. Both the hemin-controlled translational
repressor and the double-stranded RNA-activated inhibitor act by phosphorylating the M r …