[HTML][HTML] Involvement of protein kinase C δ (PKCδ) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells: lack of proteolytic cleavage of PKCδ
T Fujii, ML Garcı́a-Bermejo, JL Bernabó… - Journal of Biological …, 2000 - ASBMB
Phorbol esters, the activators of protein kinase C (PKC), induce apoptosis in androgen-
sensitive LNCaP prostate cancer cells. The role of individual PKC isozymes as mediators of
this effect has not been thoroughly examined to date. To study the involvement of the novel
isozyme PKCδ, we used a replication-deficient adenovirus (PKCδAdV), which allowed for a
tightly controlled expression of PKCδ in LNCaP cells. A significant reduction in cell number
was observed after infection of LNCaP cells with PKCδAdV. Overexpression of PKCδ …
sensitive LNCaP prostate cancer cells. The role of individual PKC isozymes as mediators of
this effect has not been thoroughly examined to date. To study the involvement of the novel
isozyme PKCδ, we used a replication-deficient adenovirus (PKCδAdV), which allowed for a
tightly controlled expression of PKCδ in LNCaP cells. A significant reduction in cell number
was observed after infection of LNCaP cells with PKCδAdV. Overexpression of PKCδ …