[HTML][HTML] Ceramide-induced Translocation of Protein Kinase C-δ and-ϵ to the Cytosol: IMPLICATIONS IN APOPTOSIS
H Sawai, T Okazaki, Y Takeda, M Tashima… - Journal of Biological …, 1997 - ASBMB
Ceramide is now recognized as an intracellular lipid signal mediator, which induces various
kinds of cell functions including apoptosis. Ceramide-induced apoptosis was reported to be
blocked by 12-O-tetradecanoylphorbol 13-acetate, a protein kinase C (PKC) activator, but its
mechanism remained unclear. Therefore, we investigated whether ceramide has any effects
on PKC in the induction of apoptosis. We here report that N-acetylsphingosine (synthetic
membrane-permeable ceramide) induced translocation of PKC-δ and-ϵ isozymes from the …
kinds of cell functions including apoptosis. Ceramide-induced apoptosis was reported to be
blocked by 12-O-tetradecanoylphorbol 13-acetate, a protein kinase C (PKC) activator, but its
mechanism remained unclear. Therefore, we investigated whether ceramide has any effects
on PKC in the induction of apoptosis. We here report that N-acetylsphingosine (synthetic
membrane-permeable ceramide) induced translocation of PKC-δ and-ϵ isozymes from the …