Activation of the bradykinin B2 receptor in endothelial cells initiates a complex array of
cellular responses mediated by diverse signaling pathways, including stimulation of the
mitogen-activated protein (MAP) kinase cascade and activation of the endothelial isoform of
nitric-oxide synthase (eNOS). Several protein kinases have been implicated in eNOS
regulation, but the role of MAP kinases remains less well understood. We explored the
interactions between eNOS and components of the MAP kinase pathway in bovine aortic …