C6 glioma cell invasion and migration of rat brain after neural homografting: ultrastructure

JJ Bernstein, WJ Goldberg, ER Laws Jr, D Conger… - …, 1990 - journals.lww.com
C6 tumor cells (106) were grafted as suspensions into freshly made implantation pockets in
rat host cerebral cortex. Specimens were prepared for transmission and scanning electron
microscopy 1 to 7 days postimplantation (DPI). By 3 DPI vacuolated C6 cells had migrated
on or invaded the host brain. C6 cells were observed on the glia limitans on the surface of
the brain, in the corpus callosum, subependymal space, and perivascular space and had
invaded the cortex under the implantation pocket. In addition to the tumor mass that was …