Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
P Kisielow, H Blüthmann, UD Staerz, M Steinmetz… - Nature, 1988 - nature.com
P Kisielow, H Blüthmann, UD Staerz, M Steinmetz, H Von Boehmer
Nature, 1988•nature.comThe mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a
receptor in many of their T cells for the male (H–Y) antigen in the context of class IH–2Db
MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only
transgene-expressing cells with a relatively high surface-density of CDS molecules,
including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.
receptor in many of their T cells for the male (H–Y) antigen in the context of class IH–2Db
MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only
transgene-expressing cells with a relatively high surface-density of CDS molecules,
including nonmature CD4+ CD8+ thymocytes, and is not caused by anti-idiotype cells.
Abstract
The mechanism of self-tolerance is studied in T-cell-receptor transgenic mice expressing a receptor in many of their T cells for the male (H–Y) antigen in the context of class I H–2Db MHC antigens. Autospecific T cells are deleted in male mice. The deletion affects only transgene-expressing cells with a relatively high surface-density of CDS molecules, including nonmature CD4+CD8+ thymocytes, and is not caused by anti-idiotype cells.
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