Nitric oxide synthase activities in human myocardium

AJ de Belder, HJF Why, PJ Richardson, CA Bucknall… - The Lancet, 1993 - Elsevier
AJ de Belder, HJF Why, PJ Richardson, CA Bucknall, JF Martin, MW Radomski, E Salas
The Lancet, 1993Elsevier
Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in
right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant
activity of inducible enzyme was accompanied by a low activity of the constitutive NO
synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may
have a physiological as well as a pathological role in the human myocardium. Lancet 1993;
341: 84-85.
Abstract
Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium. Lancet 1993; 341: 84-85.
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